The gene-editing beyond CRISPR market

Roots Analysis has announced the addition of “Gene-Editing Beyond CRISPR: Focus on ZFN, TALENs and Meganucleases Market, 2021-2035” report to its list of offerings.


The ability of gene editing solutions to directly target and modify genomic sequences has greatly expedited the progress of gene editing therapies into clinical stages. The future opportunity within the gene editing market has been segmented across [A] type of payment (upfront payment and milestone payment) and [B] geography (North America, Europe, and Asia Pacific and rest of the world).


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Key Market Insights


Presently, close to 50 drug candidates are being evaluated across different phases of development

More than 40% of the drugs have reached clinical stage of development; of these, one drug named ZFN-758 has entered the phase II stage. This is followed by 57% drugs which are being investigated in preclinical and discovery stages.


More than 1,300 patients have been enrolled in over 28 clinical trials, worldwide

Clinical research activity, in terms of number of trials registered, is reported to have increased in the last five years. Of the total number of trials, more than 30% have already been completed, while 56% are active and still recruiting patients.


Close to 1,300 articles focused on ZFN, TALENs and Meganucleases have been published, since 2016

Owing to the rising research efforts led by several industry and non-industry players in this domain, a number or peer reviewed articles have been published in reputed scientific journals. It is worth highlighting that, in 2021 (till June) 561 articles related to TALENs were published.


Close to 20 partnerships have been inked among various industry and non-industry players

The maximum number of partnerships were established in 2021, indicating a recent rise in the interest of players involved in this domain. It is worth highlighting that, majority of the deals were licensing agreements, representing over 28% of the total number of partnerships signed followed by research and development (18%), research, development and commercialization (18%), product development and commercialization (12%), product development (12%) and clinical trial (12%) agreements.



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Key Questions Answered

  • Who are the players engaged in the development of gene editing therapies beyond CRISPR?
  • Which are the key drugs being developed across early and late stages of development?
  • Which companies are actively involved in conducting clinical trials for ZFNs, TALENs and Meganucleases based therapies?
  • What is the focus area of various publications related to ZFNs, TALENs and Meganucleases based therapies?
  • What kind of partnership models are commonly adopted by industry stakeholders?
  • What is the trend of capital investments in the gene editing beyond CRISPR market?
  • How has the intellectual property landscape related to ZFNs, TALENs and Meganucleases based therapies evolved over the years?
  • How is the current and future opportunity, related to ZFNs, TALENs and Meganucleases based therapies, likely to be distributed across key market segments?


The financial opportunity within the gene editing technologies market has been analyzed across the following key geographical regions, including: 

  • North America
  • Europe
  • Asia Pacific



The research includes detailed profiles of key players (listed below) engaged in the development of gene editing technologies; each profile features an overview of the company, its financial information (if available), details on product portfolio, recent developments, and an informed future outlook.

  • Allogene Therapeutics
  • bluebird bio
  • Cellectis
  • Cytovia Therapeutics
  • Iovance Biotherapeutics
  • Precision Biosciences
  • Sangamo Therapeutics


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You may also be interested in the following titles:

  1. CRISPR based Therapeutic Market by Type of Therapy, 2021-2030
  2. Gene Editing Services Market- Focus on CRISPR, 2019-2030


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